Succession and Schitt's Creek were the big winners at the 72nd Primetime Emmy Awards, which were held virtually amid the coronavirus pandemic.
Schitt's Creek won nine prizes - breaking the Emmys record for most wins in a single season for a comedy.
It was a glowing send-off for the Canadian series, which broadcast its sixth and final season this year.
Succession took home the night's top prize, best drama series, as well as best actor for Jeremy Strong.
The HBO series also won prizes in the drama categories for best writing and best directing.
"This is such a very nice moment," said the show's British creator Jesse Armstrong in his acceptance speech, which was beamed to the ceremony from London. "But it's sad not to be with the cast and crew."
It was a significantly lower-key event this year, with most winners dialling in to make their acceptance speeches from home.
The ceremony was presented by comedian Jimmy Kimmel, with a few guest presenters joining him in the studio.Image copyright Alamy Image caption Left to right: Schitt's Creek stars Catherine O'Hara, Annie Murphy, Dan Levy and Eugene Levy
Schitt's Creek won the best comedy series prize, with its stars Catherine O'Hara and Eugene Levy being named best comedy actress and actor respectively.
Daniel Levy and Annie Murphy, meanwhile, won the best supporting actor and actress trophies.
Schitt's Creek broadcast its sixth and final season earlier this year.
The Canadian comedy series, which was created by father-son duo Eugene and Dan Levy, follows the wealthy Rose family, who are forced to move to a motel in a small town after losing their fortune.
The show launched on Pop TV in 2015 but developed a strong fan following around the world after later being added to Netflix.
Its wins also included outstanding directing for a comedy series for Andrew Cividino and Daniel Levy, with the latter also winning outstanding writing for the finale episode Happy Ending.
"Our show, at its core, is about the transformational effects of love and acceptance, and that is something we need more of now than we've ever needed before," said Dan Levy as he accepted the prize for best comedy series.
Paying tribute to his son, Eugene Levy added: "I want to thank this young man who took our fish-out-of-water story and transformed it into a story of inclusivity, a castigation of homophobia, and a declaration of the power of love, so thank you Daniel."Image copyright Getty Images Image caption Oscar winner Regina King stars in HBO superhero series Watchmen
Best drama actress went to Zendaya for Euphoria, a teen drama which follows a group high school students as they grapple with issues of love, sex, drugs and identity.
Regina King was named best actress in a limited series for her performance in Watchmen.
"This is freakin' weird!" joked the star as the Emmy was presented to her at her home.
In her acceptance speech, she paid tribute to US Supreme Court Justice Ruth Bader Ginsburg, who died over the weekend, and encouraged viewers to register vote in the forthcoming presidential election.
Her co-star Yahya Abdul-Mateen II was also named best supporting actor for his performance in the show.
Watchmen, an innovative reimagining of a superhero graphic novel that tackled racism in America, scored the most nominations this year.
It won a loyal following and critical acclaim last year during its nine-episode run.Image copyright EPA Image caption Jimmy Kimmel hosted the show, with the nominees dialling in from home
Succession's creator Jesse Armstrong also won best writing for a drama, while Andrij Parekh won best directing.
"I want to dedicate this award to all the kids whose names, like mine, are difficult to pronounce," Parekh said in his acceptance speech.
"To those who don't look like their classmates, and are defined as outsiders... This is proof that you belong, and this Emmy is ours."
This year marked Kimmel's third time hosting the Emmys, after he fronted the ceremony in 2012 and 2016.
The Creative Arts Emmys took place earlier this week, with winners announced in categories such as casting, hair, make-up, lighting and sound design.
More than 25,000 members of the Television Academy vote for the awards, which were first presented in 1949.
The name Emmy derives from an early piece of TV equipment called the image orthicon camera tube - or the Immy.