The coronavirus crisis could "level down" the UK economy with London and the South East expected to bounce back more quickly than Hull and Bradford.
Industries such as finance and construction will be worst hit by the pandemic, a report from the Social Market Foundation (SMF) has warned.
Initially, that means London and the South East will be worst affected.
However, other areas face a more painful recovery from the impact of the virus, the centrist think tank said.
The BBC has approached the government for comment.
The worst-affected areas in the short-term:
Camden and City of London Kingston, Chelsea, Hammersmith and Fulham Lambeth East Lancashire Hounslow and Richmond upon Thames Ealing Tower Hamlets Westminster Swindon West Essex"After the financial crisis, London recovered quickly because of a concentration of jobs in banking and insurance," the report said.
"Whilst these jobs will face the biggest initial blow from coronavirus, evidence suggests the capital is more economically resilient and the labour market will recover quicker than the rest of the country."
But that is not the case in areas where unemployment rates were above the UK's average of 3.8% last year, according to the SMF.
It said those areas, which include Manchester and Peterborough, face the slowest recovery.
The areas that will find it hardest to bounce back:
Hull Bradford Walsall Manchester Peterborough Lambeth Thurrock Brent Redbridge and Waltham Forest Sandwell"Policy makers need to recognise that national or even regional data can conceal the local realities of this recession and should not rely on it when making important decisions for the recovery from coronavirus," said Amy Norman from the SMF.
"The economic severity of coronavirus will be felt across many places, but we must remember that this recession does not occur in isolation," she said.
"Many people and places outside of the capital will be particularly vulnerable due to the lasting hardships of the past decade."
The report also found that young people were more vulnerable to the economic impacts of the virus crisis.
It said people between the ages of 20 and 24 were least likely to work in sectors like education, health or public administration, which have seen fewer people furloughed or made redundant.
"Young people's jobs are most at risk, but a quarter of older workers also face job instability," Ms Norman said.
"Politicians have announced the guaranteed youth opportunity but are light on support for those in older categories who will find themselves out of work."